The only lipid-soluble endogenously synthesized antioxidant, CoQ10 (ubiquinone) has well established roles as a free radical scavenger in both mitochondrial and lipid membranes, as an electron carrier essential to cellular respiration and ATP production and recently has it has been shown to influence gene expression.
Given the central role of CoQ10 in mitochondrial function and cellular antioxidant protection, its clinical applications are extensive. Just a few of the many health conditions associated with requiring supplemental CoQ10 to boost levels are: general antioxidant support, cardiovascular disease (high blood pressure, congestive heart failure, cardiomyopathy, protection during cardiac surgery, high cholesterol being treated by drugs, especially statins), cancer (to boost immune function and/or offset chemotherapy side effects), diabetes mellitus, male infertility, Alzheimer’s (prevention) and Parkinson’s disease (prevention and treatment), periodontal disease and macular degeneration. The reduced form of CoQ10, ubiquinol, has emerged as a more effective therapy for increasing plasma levels of CoQ10 than most forms of ubiquinone due to its increased solubility.
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