{"product_id":"bioclinic-estrovantage-em","title":"BioClinic-EstroVantage EM - 90vcaps","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv class=\"uses_benefits\"\u003e\n\u003ch3\u003eBenefits\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eIGF-1 has a known pathogenic role in cancer, increasing growth of existing cancer cells. Lycopene supplementation decrease IGF-1 by 25%.\u003csup\u003e7\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eIn a 34 patient randomized controlled trial foods enriched with bioactive compounds, including rosemary extract (\u003cem\u003eRosemarinus officinalis\u003c\/em\u003e), were found to be a promising adjuvant therapy in advanced breast cancer patients\u003csup\u003e8\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eGreen tea polyphenols inhibit the proliferation of breast cancer cells\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ein vivo\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ein vitro\u003c\/em\u003e\u003csup\u003e9\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSilymarin can down-regulate gene products involved in the proliferation of tumour cells (cyclin D1, EGFR, COX-2, TGF-beta, IGF-IR), invasion (MMP-9), angiogenesis (VEGF) and metastasis (adhesion molecules)\u003csup\u003e10\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eCurcumin inhibits human breast cancer cell growth by mediating certain signalling cascades including the modulation of the NF-κB signalling pathway\u003csup\u003e11\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSulforaphane can inhibit the expression of estrogen receptor alpha (ERalpha) protein in MCF-7 cells, inhibiting proliferation and down-regulating hormone receptor expression\u003csup\u003e12\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eSuitable for vegetarians\/vegans \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"feature_summary\"\u003e\n\u003ch3\u003eFeature Summary\u003c\/h3\u003e\n\u003cp\u003eIn general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17β-estradiol.\u003csup\u003e1\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eIn premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestrone (4-OHE1), 4-hydroxyestradiol (4-OHE2) and 16α-hydroxyestrone (16α-OHE1). Both 16α-OHE1 and 2-OHE have contrasting biological activities at the cellular level with 16α-OHE1 being an estrogen agonist and proliferative, while 2-OHE is an estrogen antagonist and antiproliferative.\u003csup\u003e2\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eAs such, an increased ratio 2-OHE:16α-OHE1 is associated with a reduced risk of invasive breast cancer risk in premenopausal women.\u003csup\u003e3\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eSeveral natural products found in EstroVantage EM support this latter concept including DIM, and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events.\u003csup\u003e4\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eOther compounds in EstroVantage EM, including calcium-d-glucarate, inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption.\u003csup\u003e5\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eIt is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.\u003csup\u003e6\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"BioClinic Naturals","offers":[{"title":"Default Title","offer_id":19113701965878,"sku":"AN-9672","price":51.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0739\/9733\/products\/Bioclinic_-_Estrovantage_95e42f2f-8c5c-4fab-8a65-05c7f1bd8ee9.png?v=1645894762","url":"https:\/\/store.whitelotusclinic.ca\/products\/bioclinic-estrovantage-em","provider":"White Lotus Clinic","version":"1.0","type":"link"}